Molecular mechanisms for targeted ASD treatments

New Assessments and Treatments in ASD.

OPINION STATEMENT The assessment of autism spectrum disorder (ASD) is complex and remains clinical, despite advances in basic research. In this chapter, we review new and updated clinical tools, such as screening and diagnostic tests, and discuss the DSM-5 criteria introduced in 2013. We provide an algorithm to guide clinical evaluation and referrals. We also review non-behavioral treatments an...

ASD Pathogenesis and Emerging Treatments: Lessons Learned from the Monogenic Syndromic ASD

Autism Spectrum Disorder (ASD) is a group of complex neurodevelopmental disorders characterized by social impairments and repetitive behaviors. It can be divided into two major subcategories: 1) nonsyndromic (sporadic or idiopathic) ASD and 2) syndromic ASD that also manifests other characteristic medical conditions and physical features. ASD is a growing public health crisis as its prevalence ...

possible molecular mechanisms for paramecium learning

learning is a cornerstone of intelligent behavior in animals. this behavior has been mostly studied in organisms with a fairly complex nervous system. however, recent reports of learning in unicellular organisms suggested the existence of associative learning in unicellular organisms. in particular, the capability to associate different light intensities with cathodal stimulation in paramecium ...

PDE4-targeted treatments for autoimmune diseases

Phosphodiesterase 4-targeted treatments for autoimmune diseases

Advancements in phosphodiesterase (PDE)-targeted therapies have shown promise in recent years for treating patients with a variety of autoimmune diseases. This review summarizes the development of PDE4 inhibitors and the associated literature with a focus on treatments for autoimmune diseases. After the initial investigations of the prototypic PDE inhibitor, rolipram, more selective inhibitors ...